What is apathy? It's ice in the heart and a death in the brain.

You seem very angry. What's wrong?

(What's wrong? What's the matter?)

C: What do you want?
P: Don't be impolite, child! Those words are improper!

A: What are these things?
B: I don't know, but don't touch them! They look dangerous.

What do you see?

What on earth is that?

What did she say?
(The sentence above is acceptable Na'vi, but it's not the best style. The reason is that they're using forms of the catch-all word 'u, 'thing'—you're talking about saying a thing.)

What is your favorite way to have fun?

What does little you want from me?
Note that while ngatsyìp was endearing in the previous example, here it's disparaging. To tell which is which, you need to consider the context, facial expressions, and body language.